Nineteen of the Russian's 21 victories have been achieved on hard surfaces
A comeback Medvedev won his maiden title for 882 days with success over Corentin Moutet in the competition final.
The athlete, a ex- number one, has endured a challenging season, managing just a single victory at the big events and undergoing a meltdown at the US Open.
His inconsistency on the professional circuit - and struggles with his serve in particular - led to him exiting of the elite rankings and ultimately separating with long-term trainer Cervara.
Now collaborating with his coach and his other coach, he has gradually advanced in the last few weeks - peaking in a hard-fought three-set win over Frenchman Moutet.
It is Medvedev's first championship following the Italian tournament and maiden on a hardcourt after March of 2023.
Success also signifies the Russian has achieved 21 championships at 21 different competitions.
"It's the first time I have attended a tournament with my two daughters together, so to get a championship is really nice," said world number 14 Medvedev.
"This championship is in tribute of my second daughter Victoria, because the initial championship I achieved when my child Alisa was born was for her."
The tennis star, the 2021 US Open champion, had failed in his previous six championship matches, comprising in Halle in the past months.
The player's retrieving approach and regular emotional displays on the playing surface had led observers to wonder if his ability to compete at the highest level was concluded.
However the athlete has made changes in recent weeks, making an effort to advance forward and play positively, backed up by an better service.
He fought back from a disadvantage in the first set against the challenging Frenchman, winning four of the final five exchanges to gain the advantage.
The competitors traded service breaks in the second set before the Frenchman, bidding for his maiden professional victory, took control to push for a decider.
Moutet saved 4 early chances in a close final set before Medvedev secured a break to that score to serve for the match.
Appropriately, Medvedev earned victory with a shot at the net, with Moutet unable to handle a shot after a lengthy match.
